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Trains from Sant’Ambrogio to Palermo

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  1. Home
  2. Train times
  3. Sant’Ambrogio to Palermo

Travel from Sant’Ambrogio to Palermo by train in 16 hours 54 minutes

If you want to know more about the journey from Sant’Ambrogio to Palermo by train, look no further!

The average journey time from Sant’Ambrogio to Palermo by train is 20 hours 26 minutes, although on the fastest services it can take just 16 hours 54 minutes. Around 11 trains per day travel the 573 miles (922 km) between these two destinations. You'll need to make 2 changes along the way to Palermo.

Book train tickets from Sant’Ambrogio to Palermo in advance instead of buying them on the day and you'll snap up the cheapest fares. You can check prices from Sant’Ambrogio to Palermo in our Journey Planner.

Ready to book? Start your search for cheap train tickets with us today. Keep reading for more information, including our timetable where you can view first and last train times, as well as tips on how to find cheap train tickets.

Trains to Palermo from Sant’Ambrogio

First train

05:41

Last train

20:41

Departure stationSant’Ambrogio
Arrival stationPalermo
Journey time

From 16h 54m

Distance

573 miles (922 km)

Frequency

11 trains per day

Changes

2 changes

What do people frequently ask about the train journey from Sant’Ambrogio to Palermo?

Want to know more about your journey from Sant’Ambrogio to Palermo? We've compiled some of the most frequently asked questions by our customers to help you plan your journey.

How do you travel to Palermo from Sant’Ambrogio?

To get to Palermo from Sant’Ambrogio, why not take the train? With 11 trains per day and an average journey time of 20 hours and 26 minutes, taking the train is a great way to travel. See our Journey Planner for up-to-date times and prices.

How long does it take to get from Sant’Ambrogio to Palermo by train?

On average, it takes around 20 hours and 26 minutes to travel from Sant’Ambrogio to Palermo by train, although you can get there in 16 hours and 54 minutes on the fastest services. With 11 trains per day running on this route, journey times may vary, so check our Journey Planner for more information.

How fast can trains travel from Sant’Ambrogio to Palermo?

The fastest time a train can travel the 573 miles (922 km) from Sant’Ambrogio to Palermo is 16 hours and 54 minutes.

Are there any direct trains from Sant’Ambrogio to Palermo?

There are no direct trains that run between Sant’Ambrogio and Palermo. You’ll need to make at least 2 changes along the way.

What are the train times from Sant’Ambrogio to Palermo?

Check out the next trains departing from Sant’Ambrogio to Palermo for Tuesday 25th November 2025. For the full train timetable/schedule, or to search for a later time or date, click here.
DepartsArrivesDuration
04:4122:3517h 54m, 2 changes
05:4122:3516h 54m, 3 changes
10:4106:5220h 11m, 4 changes
13:4108:2218h 41m, 2 changes
14:4112:3221h 51m, 3 changes
14:4112:3421h 53m, 2 changes
15:4112:3220h 51m, 4 changes
15:4112:3420h 53m, 3 changes
17:4115:5522h 14m, 2 changes
19:4116:2620h 45m, 4 changes

How do I find cheap train tickets from Sant’Ambrogio to Palermo?

If you’re planning a trip to Europe soon, our Trainline team of experts have put together some tips to help you find cheap tickets. Booking on the day in Europe is usually more expensive and costs can vary depending on the time of day, route or travel class.

1. Book in advance

The price of train tickets from Sant’Ambrogio to Palermo starts at § one-way for a Standard Class ticket if you book in advance. Most train companies across Europe release their tickets around three to six months ahead of time, so if you know the dates you want to travel, you may be able to find cheaper tickets.

2. Be flexible with your travel times

If you can, consider travelling outside of 'peak hours' (generally between 06:00 - 10:00 and 15:00 - 19:00 on weekdays) as many train companies increase their ticket prices during these commuter times.

3. Buy a rail pass

If you're visiting multiple locations on your trip, buying a rail pass can be cheaper than buying individual tickets. We're official retailers of Interrail Passes that are valid for travel within one country or multiple countries across Europe.

4. Choose a slower or connecting train

On some busier routes, you might have the option to take a slower or connecting train. It may take longer than some high-speed or direct services, but if you have some extra time on your hands, you might find a cheaper fare.

5. Look out for train ticket sales and discounts

Many train companies in Europe will often run sales on tickets throughout the year or offer discounts to senior/youth/group travellers, so keep an eye out!

6. Take a night train

Save on accommodation and use the night to travel by sleeper train to your next destination.

For specific information about how to get your hands on cheap tickets, check out our European train tickets hub.

§Some train companies may not offer any Advance ticket types or cheaper deals for early bookings. On rare occasions, train companies may choose to release special offers closer to the date on last-minute or late-release tickets. This is dependent on the individual train operating company you travel with.

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