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Trains from Pisa Centrale to Frankfurt (Main) Hbf

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  3. Pisa Centrale to Frankfurt (Main) Hbf

Taking the train from Pisa Centrale to Frankfurt (Main) Hbf in 10 hours 43 minutes

Thinking about taking the train from Pisa Centrale to Frankfurt (Main) Hbf? We’ve got you covered.

It usually takes around 13 hours 44 minutes to travel the 450 miles (724 km) from Pisa Centrale to Frankfurt (Main) Hbf by train, although you can get there in as little as 10 hours 43 minutes on the fastest services. You’ll normally find around 30 trains per day running on this route. You’ll need to make 1 change along the way as there aren't any direct services on this line.

Train tickets from Pisa Centrale to Frankfurt (Main) Hbf start from £122.82 when you book in advance, which can be cheaper than buying them on the day. Start a search in our Journey Planner to check out the latest prices.

Keen to book your train tickets to Frankfurt (Main) Hbf? No need to wait, start a search with us today! If you want to find out a bit more about the journey first, you can find our train timetable below, tips on booking cheap tickets and our FAQs, including first and last train times.

Trains to Frankfurt (Main) Hbf from Pisa Centrale

It takes an average of 13h 44m to travel from Pisa Centrale to Frankfurt (Main) Hbf by train, over a distance of around 450 miles (724 km). There are normally 30 trains per day travelling from Pisa Centrale to Frankfurt (Main) Hbf and tickets for this journey start from £122.82 when you book in advance.

First train

03:26

Last train

22:53

Departure stationPisa Centrale
Arrival stationFrankfurt (Main) Hbf
Journey time

From 10h 43m

Distance

450 miles (724 km)

Frequency

30 trains per day

Changes

1 change

Price

From £122.82

Train and bus operators

Flixbus

What do people frequently ask about the train journey from Pisa Centrale to Frankfurt (Main) Hbf?

Want to know more about your journey from Pisa Centrale to Frankfurt (Main) Hbf? We've compiled some of the most frequently asked questions by our customers to help you plan your journey.

How do you travel to Frankfurt (Main) Hbf from Pisa Centrale?

To get to Frankfurt (Main) Hbf from Pisa Centrale, why not take the train? With 30 trains per day and an average journey time of 13 hours and 44 minutes, taking the train is a great way to travel. You can also catch the bus from Pisa Centrale to Frankfurt (Main) Hbf. See our Journey Planner for up-to-date times and prices.

How long does it take to get from Pisa Centrale to Frankfurt (Main) Hbf by train?

On average, it takes around 13 hours and 44 minutes to travel from Pisa Centrale to Frankfurt (Main) Hbf by train, although you can get there in 10 hours and 43 minutes on the fastest services. With 30 trains per day running on this route, journey times may vary, so check our Journey Planner for more information.

How much is the train ticket from Pisa Centrale to Frankfurt (Main) Hbf?

The price of a train ticket from Pisa Centrale to Frankfurt (Main) Hbf can start from as little as £122.82, depending on the time of day, route and class you book. Train tickets may also be cheaper when you book in advance compared to buying them on the day.

How fast can trains travel from Pisa Centrale to Frankfurt (Main) Hbf?

The fastest time a train can travel the 450 miles (724 km) from Pisa Centrale to Frankfurt (Main) Hbf is 10 hours and 43 minutes.

What are the train times from Pisa Centrale to Frankfurt (Main) Hbf?

Check out the next trains departing from Pisa Centrale to Frankfurt (Main) Hbf for Tuesday 14th October 2025. For the full train timetable/schedule, or to search for a later time or date, click here.
DepartsArrivesDuration
08:0918:5210h 43m, 5 changes
08:3220:0811h 36m, 3 changes
10:3022:0811h 38m, 3 changes
10:4223:4112h 59m, 4 changes
11:3223:4112h 9m, 5 changes
12:3201:4013h 8m, 4 changes
12:3901:4513h 6m, 2 changes
13:3201:4512h 13m, 3 changes
13:5608:5218h 56m, 2 changes
15:3207:0815h 36m, 5 changes

How do I find cheap train tickets from Pisa Centrale to Frankfurt (Main) Hbf?

If you’re planning a trip to Europe soon, our Trainline team of experts have put together some tips to help you find cheap tickets. Booking on the day in Europe is usually more expensive and costs can vary depending on the time of day, route or travel class.

1. Book in advance

The price of train tickets from Pisa Centrale to Frankfurt (Main) Hbf starts at £122.82§ one-way for a Standard Class ticket if you book in advance. Most train companies across Europe release their tickets around three to six months ahead of time, so if you know the dates you want to travel, you may be able to find cheaper tickets.

2. Be flexible with your travel times

If you can, consider travelling outside of 'peak hours' (generally between 06:00 - 10:00 and 15:00 - 19:00 on weekdays) as many train companies increase their ticket prices during these commuter times.

3. Buy a rail pass

If you're visiting multiple locations on your trip, buying a rail pass can be cheaper than buying individual tickets. We're official retailers of Interrail Passes that are valid for travel within one country or multiple countries across Europe.

4. Choose a slower or connecting train

On some busier routes, you might have the option to take a slower or connecting train. It may take longer than some high-speed or direct services, but if you have some extra time on your hands, you might find a cheaper fare.

5. Look out for train ticket sales and discounts

Many train companies in Europe will often run sales on tickets throughout the year or offer discounts to senior/youth/group travellers, so keep an eye out!

6. Take a night train

Save on accommodation and use the night to travel by sleeper train to your next destination.

For specific information about how to get your hands on cheap tickets, check out our European train tickets hub.

§Some train companies may not offer any Advance ticket types or cheaper deals for early bookings. On rare occasions, train companies may choose to release special offers closer to the date on last-minute or late-release tickets. This is dependent on the individual train operating company you travel with.

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