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Trains from Pisa Centrale to Frankfurt (Main) Hbf

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Each fare is the lowest adult economy ticket fare found by our customers on Trainline. Fares booked further in advance than the dates displayed may be cheaper. Prices are updated daily, subject to change and indicative of price last update. Limited availability. Discount cards and coach journeys excluded, prices exclusive of booking fee.

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  3. Pisa Centrale to Frankfurt (Main) Hbf

Taking the train from Pisa Centrale to Frankfurt (Main) Hbf in 11 hours 2 minutes

Thinking about taking the train from Pisa Centrale to Frankfurt (Main) Hbf? We’ve got you covered.

It usually takes around 13 hours 33 minutes to travel the 450 miles (724 km) from Pisa Centrale to Frankfurt (Main) Hbf by train, although you can get there in as little as 11 hours 2 minutes on the fastest services. You’ll normally find around 18 trains per day running on this route. You’ll need to make 2 changes along the way as there aren't any direct services on this line.

Train tickets from Pisa Centrale to Frankfurt (Main) Hbf start from £160.09 when you book in advance, which can be cheaper than buying them on the day. Start a search in our Journey Planner to check out the latest prices.

Keen to book your train tickets to Frankfurt (Main) Hbf? No need to wait, start a search with us today! If you want to find out a bit more about the journey first, you can find our train timetable below, tips on booking cheap tickets and our FAQs, including first and last train times.

Trains to Frankfurt (Main) Hbf from Pisa Centrale

It takes an average of 13h 33m to travel from Pisa Centrale to Frankfurt (Main) Hbf by train, over a distance of around 450 miles (724 km). There are normally 18 trains per day travelling from Pisa Centrale to Frankfurt (Main) Hbf and tickets for this journey start from £160.09 when you book in advance.

First train

05:19

Last train

22:34

Departure stationPisa Centrale
Arrival stationFrankfurt (Main) Hbf
Journey time

From 11h 2m

Distance

450 miles (724 km)

Frequency

18 trains per day

Changes

2 changes

Price

From £160.09

Train and bus operators

Flixbus

What do people frequently ask about the train journey from Pisa Centrale to Frankfurt (Main) Hbf?

Want to know more about your journey from Pisa Centrale to Frankfurt (Main) Hbf? We've compiled some of the most frequently asked questions by our customers to help you plan your journey.

How do you travel to Frankfurt (Main) Hbf from Pisa Centrale?

To get to Frankfurt (Main) Hbf from Pisa Centrale, why not take the train? With 18 trains per day and an average journey time of 13 hours and 33 minutes, taking the train is a great way to travel. You can also catch the bus from Pisa Centrale to Frankfurt (Main) Hbf. See our Journey Planner for up-to-date times and prices.

How long does it take to get from Pisa Centrale to Frankfurt (Main) Hbf by train?

On average, it takes around 13 hours and 33 minutes to travel from Pisa Centrale to Frankfurt (Main) Hbf by train, although you can get there in 11 hours and 2 minutes on the fastest services. With 18 trains per day running on this route, journey times may vary, so check our Journey Planner for more information.

How much is the train ticket from Pisa Centrale to Frankfurt (Main) Hbf?

The price of a train ticket from Pisa Centrale to Frankfurt (Main) Hbf can start from as little as £160.09, depending on the time of day, route and class you book. Train tickets may also be cheaper when you book in advance compared to buying them on the day.

How fast can trains travel from Pisa Centrale to Frankfurt (Main) Hbf?

The fastest time a train can travel the 450 miles (724 km) from Pisa Centrale to Frankfurt (Main) Hbf is 11 hours and 2 minutes.

What are the train times from Pisa Centrale to Frankfurt (Main) Hbf?

Check out the next trains departing from Pisa Centrale to Frankfurt (Main) Hbf for Tuesday 27th January 2026. For the full train timetable/schedule, or to search for a later time or date, click here.
DepartsArrivesDuration
06:3817:4011h 2m, 3 changes
06:3817:4411h 6m, 2 changes
06:4418:4011h 56m, 4 changes
08:3220:0911h 37m, 4 changes
10:3022:0911h 39m, 3 changes
11:3223:4312h 11m, 4 changes
13:3202:0812h 36m, 4 changes
15:3206:4015h 8m, 4 changes
16:0906:4014h 31m, 5 changes
17:3210:0916h 37m, 5 changes

How do I find cheap train tickets from Pisa Centrale to Frankfurt (Main) Hbf?

If you’re planning a trip to Europe soon, our Trainline team of experts have put together some tips to help you find cheap tickets. Booking on the day in Europe is usually more expensive and costs can vary depending on the time of day, route or travel class.

1. Book in advance

The price of train tickets from Pisa Centrale to Frankfurt (Main) Hbf starts at £160.09§ one-way for a Standard Class ticket if you book in advance. Most train companies across Europe release their tickets around three to six months ahead of time, so if you know the dates you want to travel, you may be able to find cheaper tickets.

2. Be flexible with your travel times

If you can, consider travelling outside of 'peak hours' (generally between 06:00 - 10:00 and 15:00 - 19:00 on weekdays) as many train companies increase their ticket prices during these commuter times.

3. Buy a rail pass

If you're visiting multiple locations on your trip, buying a rail pass can be cheaper than buying individual tickets. We're official retailers of Interrail Passes that are valid for travel within one country or multiple countries across Europe.

4. Choose a slower or connecting train

On some busier routes, you might have the option to take a slower or connecting train. It may take longer than some high-speed or direct services, but if you have some extra time on your hands, you might find a cheaper fare.

5. Look out for train ticket sales and discounts

Many train companies in Europe will often run sales on tickets throughout the year or offer discounts to senior/youth/group travellers, so keep an eye out!

6. Take a night train

Save on accommodation and use the night to travel by sleeper train to your next destination.

For specific information about how to get your hands on cheap tickets, check out our European train tickets hub.

§Some train companies may not offer any Advance ticket types or cheaper deals for early bookings. On rare occasions, train companies may choose to release special offers closer to the date on last-minute or late-release tickets. This is dependent on the individual train operating company you travel with.

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