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Trains from Florence to Isernia

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  1. Home
  2. Train times
  3. Florence to Isernia

Travelling from Florence to Isernia by train

Looking to travel from Florence to Isernia by train? You've come to the right place!

On average, it takes around 6 hours 9 minutes to travel from Florence to Isernia by train, the fastest services can get you there in as little as 3 hours 59 minutes though. You'll usually find 26 trains per day running along the 213 miles (343 km) route between these two destinations. You’ll need to make 1 change during the journey to Isernia, as there currently aren't any direct services on this route.

Plan your trip ahead and book your train tickets in advance if you want to snap up the cheapest fares. Just start a search in our Journey Planner to view the latest prices for trains from Florence to Isernia.

If you’re feeling ready to book, start looking for cheap train tickets with us today. Keep reading for more information on the journey to Isernia by train, including our timetable where you can view first and last train times.

Trains to Isernia from Florence

First train

07:05

Last train

22:43

Departure stationFlorence
Arrival stationIsernia
Journey time

From 3h 59m

Distance

213 miles (343 km)

Frequency

26 trains per day

Changes

1 change

Train and bus operators

Flixbus

What do people frequently ask about the train journey from Florence to Isernia?

Want to know more about your journey from Florence to Isernia? We've compiled some of the most frequently asked questions by our customers to help you plan your journey.

How do you travel to Isernia from Florence?

To get to Isernia from Florence, why not take the train? With 26 trains per day and an average journey time of 6 hours and 9 minutes, taking the train is a great way to travel. See our Journey Planner for up-to-date times and prices.

How long does it take to get from Florence to Isernia by train?

On average, it takes around 6 hours and 9 minutes to travel from Florence to Isernia by train, although you can get there in 3 hours and 59 minutes on the fastest services. With 26 trains per day running on this route, journey times may vary, so check our Journey Planner for more information.

How fast can trains travel from Florence to Isernia?

The fastest time a train can travel the 213 miles (343 km) from Florence to Isernia is 3 hours and 59 minutes.

Are there any direct trains from Florence to Isernia?

There are no direct trains that run between Florence and Isernia. You’ll need to make at least 1 change along the way.

What are the train times from Florence to Isernia?

Check out the next trains departing from Florence to Isernia for Tuesday 14th October 2025. For the full train timetable/schedule, or to search for a later time or date, click here.
DepartsArrivesDuration
11:4815:473h 59m, 1 change
12:1418:306h 16m, 2 changes
12:4318:055h 22m, 1 change
12:4818:305h 42m, 3 changes
12:4818:055h 17m, 2 changes
14:1419:205h 6m, 1 change
14:4819:204h 32m, 2 changes
14:4818:544h 6m, 1 change
15:1419:554h 41m, 2 changes
15:2820:405h 12m, 1 change

How do I find cheap train tickets from Florence to Isernia?

If you’re planning a trip to Europe soon, our Trainline team of experts have put together some tips to help you find cheap tickets. Booking on the day in Europe is usually more expensive and costs can vary depending on the time of day, route or travel class.

1. Book in advance

The price of train tickets from Florence to Isernia starts at § one-way for a Standard Class ticket if you book in advance. Most train companies across Europe release their tickets around three to six months ahead of time, so if you know the dates you want to travel, you may be able to find cheaper tickets.

2. Be flexible with your travel times

If you can, consider travelling outside of 'peak hours' (generally between 06:00 - 10:00 and 15:00 - 19:00 on weekdays) as many train companies increase their ticket prices during these commuter times.

3. Buy a rail pass

If you're visiting multiple locations on your trip, buying a rail pass can be cheaper than buying individual tickets. We're official retailers of Interrail Passes that are valid for travel within one country or multiple countries across Europe.

4. Choose a slower or connecting train

On some busier routes, you might have the option to take a slower or connecting train. It may take longer than some high-speed or direct services, but if you have some extra time on your hands, you might find a cheaper fare.

5. Look out for train ticket sales and discounts

Many train companies in Europe will often run sales on tickets throughout the year or offer discounts to senior/youth/group travellers, so keep an eye out!

6. Take a night train

Save on accommodation and use the night to travel by sleeper train to your next destination.

For specific information about how to get your hands on cheap tickets, check out our European train tickets hub.

§Some train companies may not offer any Advance ticket types or cheaper deals for early bookings. On rare occasions, train companies may choose to release special offers closer to the date on last-minute or late-release tickets. This is dependent on the individual train operating company you travel with.

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