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Take the train from Mainz to Palermo in 22 hours 19 minutes

If you want to travel from Mainz to Palermo by train, you've come to the right place.

You can expect the journey from Mainz to Palermo by train to take around 25 hours 55 minutes. If you want to get there as quickly as possible, it can take as little as 22 hours 19 minutes on the fastest services. You’ll usually find around 11 trains per day running on this route, which spans 859 miles (1382 km). You’ll have to make 3 changes along the way on your journey to Palermo.

You can save money on train tickets from Mainz to Palermo if you book in Use our Journey Planner at the top of the page to search for cheap ticket prices – we'll show you how much you can save on train tickets from Mainz to Palermo if you book in advance.. Use our Journey Planner at the top of the page to compare ticket prices and get the cheapest fares.

If you want to know more about the journey, keep reading for timetables, tips on finding cheap tickets and FAQs, including first and last train times. Want to go straight to booking? Start a search with us today!

Mainz to Palermo by train

First train

05:40

Last train

21:17

Departure station

Mainz

Arrival station

Palermo

Journey time

From 22h 19m

Distance

859 miles (1382 km)

Frequency

11 trains per day

Changes

3 changes

FAQs about the train journey from Mainz to Palermo

Want to know more about your journey from Mainz to Palermo? We've compiled some of the most frequently asked questions by our customers to help you plan your journey.

How do I get from Mainz to Palermo?

You can travel from Mainz to Palermo by train in about 25 hours and 55 minutes. With around 11 trains running each day, taking the train is easy. Find out more in our Journey Planner.

How long is the train journey from Mainz to Palermo?

On average, the train journey from Mainz to Palermo takes around 25 hours and 55 minutes, with 11 trains per day. The duration may vary slightly depending on the specific train and any potential delays. Use our Journey Planner to check out more information.

What is the fastest train from Mainz to Palermo?

The fastest trains from Mainz to Palermo can cover the distance of 859 miles (1382 km) in as little as 22 hours and 19 minutes.

Is there a direct train from Mainz to Palermo?

No, you can’t travel from Mainz to Palermo on a direct train, you’ll need to make at least 3 changes during the journey.

Mainz to Palermo train times

Check out the next trains departing from Mainz to Palermo for Tuesday 6th May 2025. For the full train timetable/schedule, or to search for a later time or date, click here.
DepartsArrivesDuration
04:4006:5226h 12m, 5 changes
06:2208:2226h 0m, 3 changes
07:1308:2225h 9m, 7 changes
09:4210:0124h 19m, 5 changes
09:4211:3125h 49m, 3 changes
11:4210:0122h 19m, 7 changes
11:4211:3123h 49m, 5 changes
12:1315:5527h 42m, 6 changes
12:1318:0229h 49m, 4 changes
13:4218:0228h 20m, 6 changes

Cheap train tickets from Mainz to Palermo

Book in advance

Most of the train companies across Europe release their tickets around three to six months in advance, many of which can be cheaper the earlier you book. If you know the dates you want to travel, you may be able to find some cheaper train tickets from Mainz to Palermo by booking early.§

Be flexible with your travel times

Many of the train services in Europe are also popular commuter services, lots of train companies increase ticket prices during “peak hours” (generally between 06:00 – 10:00 and 15:00 – 19:00 on weekdays). If you can, consider travelling outside of peak hours to find lower priced tickets.

Choose a slower or connecting train

On some of the busier routes, you might also have the option to take a slower or connecting train. It may take a little longer than some high-speed or direct services, but if you have a little extra time on your hands, you might find a cheaper fare. Plus, you'll have more time to enjoy the view of the countryside!

Look out for special deals

Take a look at our handy guides to find out when train operators release their special deals and offers to see if you can find cheap European train tickets for your journey.

For specific information about how to get your hands on cheap tickets, check out our European train tickets hub.

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