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Travel by train from Sant’Ambrogio to Rome

Looking to travel from Sant’Ambrogio to Rome by train? You've come to the right place!

Generally, the train from Sant’Ambrogio to Rome takes around 6 hours 30 minutes, but can take just 5 hours 6 minutes on the fastest services. There are up to 21 trains per day from Sant’Ambrogio to Rome.

You'll need to make 1 change along the way as there aren't any direct services on this line.

Booking early is one of the most effective ways to save money.

Start your search for train tickets from Sant’Ambrogio to Rome in our Journey Planner.

Trains to Rome from Sant’Ambrogio

First train

04:41

Last train

20:41

Departure stationSant’Ambrogio
Arrival stationRome
Journey time

From 5h 6m

Distance

339 miles (546 km)

Frequency

21 trains per day

Changes

1 change

What do people frequently ask about the train journey from Sant’Ambrogio to Rome?

Want to know more about your journey from Sant’Ambrogio to Rome? We've compiled some of the most frequently asked questions by our customers to help you plan your journey.

How do you get to Rome from Sant’Ambrogio?

To travel to Rome from Sant’Ambrogio, you can take the train - on average, the journey takes around 6 hours and 30 minutes, though the fastest trains can take 5 hours and 6 minutes. Use our Journey Planner to get more information.

How long is the train ride from Sant’Ambrogio to Rome?

Trains from Sant’Ambrogio to Rome take an average of 6 hours and 30 minutes, although on the fastest services it can take just 5 hours and 6 minutes. You'll usually find 21 trains per day on this route, so use our Journey Planner to check specific dates as times may vary.

What is the quickest journey time between Sant’Ambrogio and Rome by train?

The quickest journey time between Sant’Ambrogio and Rome by train is 5 hours and 6 minutes.

Are there direct trains from Sant’Ambrogio to Rome?

No, there are no direct trains running from Sant’Ambrogio to Rome, you’ll usually need to make at least 1 change during the journey.

What are the train times from Sant’Ambrogio to Rome?

Check out the next trains departing from Sant’Ambrogio to Rome for Tuesday 6th October 2026. For the full train timetable/schedule, or to search for a later time or date, click here.
DepartsArrivesDuration
06:4112:235h 42m, 1 change
07:4113:405h 59m, 1 change
08:4114:405h 59m, 1 change
10:4116:405h 59m, 2 changes
10:4116:496h 8m, 1 change
11:4117:135h 32m, 1 change
13:0918:155h 6m, 1 change
13:4119:165h 35m, 1 change
14:4120:405h 59m, 1 change
15:4121:105h 29m, 2 changes

How do I find cheap train tickets from Sant’Ambrogio to Rome?

If you’re planning a trip to Europe soon, our Trainline team of experts have put together some tips to help you find cheap tickets. Booking on the day in Europe is usually more expensive and costs can vary depending on the time of day, route or travel class.

1. Be flexible with your travel times

If you can, consider travelling outside of 'peak hours' (generally between 06:00 - 10:00 and 15:00 - 19:00 on weekdays) as many train companies increase their ticket prices during these commuter times.

2. Buy a rail pass

If you're visiting multiple locations on your trip, buying a rail pass can be cheaper than buying individual tickets. We're official retailers of Interrail Passes that are valid for travel within one country or multiple countries across Europe.

3. Choose a slower or connecting train

On some busier routes, you might have the option to take a slower or connecting train. It may take longer than some high-speed or direct services, but if you have some extra time on your hands, you might find a cheaper fare.

4. Look out for train ticket sales and discounts

Many train companies in Europe will often run sales on tickets throughout the year or offer discounts to senior/youth/group travellers, so keep an eye out!

5. Take a night train

Save on accommodation and use the night to travel by sleeper train to your next destination.

For specific information about how to get your hands on cheap tickets, check out our European train tickets hub.

§Some train companies may not offer any Advance ticket types or cheaper deals for early bookings. On rare occasions, train companies may choose to release special offers closer to the date on last-minute or late-release tickets. This is dependent on the individual train operating company you travel with.

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