New Southgate opened in 1850 as Colney Hatch, and the station served the Colney Hatch Lunatic Asylum, which had opened around the same time. By the 1870s, the station had been renamed, as had the nearby district after residents objected to being linked too closely to the nearby hospital. Today, trains to New Southgate are part of the stopping service between London Moorgate and Welwyn Garden City. On weekdays after 10pm and on weekends, London services terminate at King's Cross.
New Southgate station serves the predominantly residential neighbourhoods of Friern Barnet as well as New Southgate itself. Places of interest nearby include the former asylum, which has now been transformed into a residential development, with the former hospital farm now the Friern Village Park. On Station Road in New Southgate, the Millennium Green is home to a commemorative statue in memory of the writer Jerome K Jerome, who lived nearby.