Located in southeast Hertfordshire, Cuffley is very much in the London commuter belt - it is fair to say that the railway had a dramatic impact on the village and the nearby settlements of Goffs Oak and Northaw when it opened in 1910. Today, commuter services link Cuffley with Moorgate, and there are evening and weekend services to King's Cross. Other services from Cuffley connect to Hertford North, Stevenage and Letchworth Garden City.
From the station it is a short walk along Station Road to the village's main row of shops, leading up to the junction with Plough Hill. A few miles to the north of the village are the Broxbourne Woods National Nature Reserve, the Paradise Wildlife Park and the Speedway Museum. Cuffley is also known as being the home of the Tolmers Scout Camp, on land that was once part of the historic Tolmers Park Estate.