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Trains run direct train from London Euston to Manchester Piccadilly 3 times per hour, and journeys take a little over 2 hours. The services are run by Virgin Trains.
On board you will find a shop selling a range of hot and cold drinks, snacks plus newspapers and magazines; and Wi-Fi (free in First Class, or available for a small fee in Standard Class). There's also on-board storage facilities for bicycles, but as space is at a premium it is best to reserve a space in advance by calling 08719 774 222 (unfortunately it's not possible to make bike reservations online).*Information correct at time of writing (March 2011). May be subject to change